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- Title
Impact of Congenital Heart Disease on Growth of Down Syndrome Children (6-36 months).
- Authors
Kotby, Alyaa A.; El Guindy, Waleed M.; Eissa, Deena Samir M.; Hussain, Abeer Mohammed H.
- Abstract
Background: Down syndrome (DS), the most common chromosomal abnormality is associated by congenital heart disease (CHD) in (44%) of cases. Children with DS might have different growth pattern compared to children without DS. Objective: To assess the impact of congenital heart disease on the growth of Down syndrome children who attend the Genetic clinic, Children’s Hospital, Ain Shams University. Materials and Methods: This case controlled study was conducted on 40 children with DS aged 6-36 months and compared to 40 age and sex matched healthy children. The DS children were divided in to two groups, the Cardiac Group: Included 20 DS children with CHD, Non Cardiac Group: 20 DS children without CHD. All children enrolled in the study were subjected to detailed history, thorough clinical examination including (anthropometric measurements (weight, height and HC) and cardiac examination. Results: A statistically highly significant decrease was found in children with DS in comparison to normal children in all evaluated anthropometric measurements (P ¼ 0.000) for weight, height, WT/length SDS, head circumference and Z-scores (weight, height and HC).A statistically highly significant decrease was found in DS children with congenital heart disease (cardiac group) in comparison with DS children without congenital heart disease (non-cardiac group) as regards weight (P ¼ 0.002), Height (P ¼ 0.000), head circumference (P ¼ 0.000), Zscores (weight) (P ¼ 0.001) and WT/length SDS (P ¼ 0.001). Conclusion: Children with trisomy 21 have well documented growth retardation. Congenital heart diseases have a negative influence on growth pattern in children with DS.
- Subjects
CONGENITAL heart disease; SYNDROMES in children; DOWN syndrome; CHILDREN'S hospitals; GROWTH of children
- Publication
QJM: An International Journal of Medicine, 2021, Vol 114, pi282
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcab113.002