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- Title
Role of Dexamethasone in Induction of Labor: (A Randomized Clinical Trial).
- Authors
Elsayed, H. M.; Bahaa, A. M.; Alanwar, A. A.; Mohamed, K. M.
- Abstract
Background: Labor induction is a common obstetric procedure which is done for many indications. Ripening of the cervix is a complex process involving hormonal, vasodilatory and inflammatory changes. There are broad range of methods for cervical ripening and induction of labor. Aim of the study: to assess the efficacy of intramuscular administration of dexamethasone on the induction delivery-interval in full term women undergoing induction of labor. Patients and Methods: This study was carried out between July 2018 and January 2019, at the labor ward of Ain Shams university maternity hospital, a double bind randomized control trial of 80 pregnant women undergoing induction of labor after obtaining the approval of the local ethical committee and a fully-informed written consent. They were randomized into two groups: group D (Dexamethasone group n=40) and group C (control group n=40). Results: Of 80 pregnant women undergoing induction of labor there were no statistically significant differences between the two groups as regard their age, body mass index, gestational age and bishop score at time of intervention. There was significant statistical difference between the two groups as regard induction-active phase interval (P<0.05), mean inductionactive phase interval in group D was (4.91±.85 hours) while in group C was (5.44±.83 hours). There was no significant statistical difference between the two groups as regard duration of active phase of labor, mean duration of active phase in group D was (4.10±.97 hours) and in group C (4.47±1.20 hours). There was significant statistical difference between the two groups as regard induction-delivery interval (P<0.05), mean inductiondelivery interval in group D was (9.73±.1.52hours) while in group C was (10.70±1.87 hours). There were no statistically significant differences between the two groups as regard duration of 2nd and 3rd stages of labor. Conclusion: Single intramuscular injections of 2 ml. (8mg) of dexamethasone before induction of labor seems to shorten induction-delivery interval by shortening the induction-active phase interval.
- Subjects
INDUCED labor (Obstetrics); CLINICAL trials; BODY mass index; STAGES of labor (Obstetrics); INTRAMUSCULAR injections; WOMEN'S hospitals
- Publication
QJM: An International Journal of Medicine, 2020, Vol 113, pi162
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcaa056.011