We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
From Synapse to Nucleus and Back Again-Communication over Distance within Neurons.
- Authors
Fainzilber, Mike; Budnik, Vivian; Segal, Rosalind A.; Kreutz, Michael R.
- Abstract
How do neurons integrate intracellular communication from synapse to nucleus and back? Here we briefly ummarize aspects of this topic covered by a symposium at Neuroscience 2011. A rich repertoire of signaling mechanisms link both dendritic terminals and axon tip with neuronal soma and nucleus, using motor-dependent transport machineries to traverse the long intracellular distances along neuronal proces e . Activation mechanisms at terminals include localized translation of dendritic or axonal RNA, proteolytic cleavage of receptor or second messengers, and differential phosphorylation of signaling moieties. Signaling complexes may be transported in endo omes, or as nonendosomal complexes associated with irnportins and dynein. Anterograde transport of RNA granules from the soma to neuronal proce se, coupled with retrograde transport of proteins translated locally at terminals or within processes, may fuel ongoing bidirectional communication between soma and synapse to modulate synaptic plasticity as well as neuronal growth and survival decisions.
- Subjects
CELL nuclei; SYNAPSES; CELLULAR signal transduction; AXONS; MOTOR ability; CELL growth; PHOSPHORYLATION
- Publication
Journal of Neuroscience, 2011, Vol 31, Issue 45, p16045
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.4006-11.2011