We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Neural Encoding of Psychomotor Activation in the Nucleus Accumbens Core, But Not the Shell, Requires Cannabinoid Receptor Signaling.
- Authors
Morra, Joshua T.; Glick, Stanley D.; Cheer, Joseph F.
- Abstract
The current study aimed to further elucidate the role of endocannabinoid signaling in methamphetamine-induced psychomotor activation. Rats were treated with bilateral, intracranial microinjections of the cannabinoid CB1 receptor antagonists rimonabant (1μg; 1μl) or AM251 (1μg; 1μl), or vehicle (1μl), followed by intravenous methamphetamine (3 mg/kg). Antagonist pretreatment in the nucleus accumbens core, but not shell, attenuated methamphetamine-induced stereotypy, while treatment in either brain region had no effect on drug-induced locomotion. In a parallel experiment, we recorded multiple single units in the nucleus accumbens of behaving rats treated with intravenous rimonabant (0.3 mg/kg) or vehicle, followed by methamphetamine (0.01, 0.1, 1, 3 mg/kg; cumulative dosing). We observed robust, phasic changes in neuronal firing time locked to the onset of methamphetamine-induced locomotion and stereotypy. Stereotypy encoding was observed in the core and was attenuated by CB1 receptor antagonism, while locomotor correlates were observed uniformly across the accumbens and were not affected by rimonabant. Psychomotor activation encoding was expressed predominantly by putative fast-spiking interneurons. We therefore propose that endocannabinoid modulation of psychomotor activation is preferentially driven by CB1 receptor-dependent interneuron activity in the nucleus accumbens core.
- Subjects
METHAMPHETAMINE; PSYCHOLOGY of movement; MICROINJECTIONS; CANNABINOIDS; RIMONABANT; NUCLEUS accumbens
- Publication
Journal of Neuroscience, 2010, Vol 30, Issue 14, p5102
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.5335-09.2010