We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Design, synthesis, and in vitro antituberculosis activity of benzo[6,7]cyclohepta[1,2- b]pyridine-1,3,4-oxadiazole derivatives.
- Authors
Sajja, Yasodakrishna; Vanguru, Sowmya; Vulupala, Hanmanth Reddy; Nagarapu, Lingaiah; Perumal, Yogeswari; Sriram, Dharmarajan; Nanubolu, Jagadeesh Babu
- Abstract
A new antitubercular agents, benzo[6,7]cyclohepta[1,2- b]pyridine-1,3,4- oxadiazole hybrids ( 6a-o), have been designed and synthesized involving oxidative cyclization of hydrazones by use of di(acetoxy)iodobenzene, characterized by IR,1H NMR,13C NMR, and HRMS, and further confirmed by X-ray analysis. All the newly synthesized compounds 4a-o evaluated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv ( ATCC27294). Among the compounds tested, the compounds 4o ( MIC: 1.56 μg/ml) and 4l, 4m ( MIC: 3.125 μg/ml) are promising lead analogues and have shown lower cytotoxicity.
- Subjects
ANTITUBERCULAR agents; IN vitro studies; OXADIAZOLES; RING formation (Chemistry); OXIDATION
- Publication
Chemical Biology & Drug Design, 2017, Vol 90, Issue 4, p496
- ISSN
1747-0277
- Publication type
Article
- DOI
10.1111/cbdd.12969