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- Title
CEACAM5 is an IL‐13‐regulated epithelial gene that mediates transcription in type‐2 (T2) high severe asthma.
- Authors
Mumby, Sharon; Kermani, Nazanin Zounemat; Garnett, James P.; Pavlidis, Stelios; Wilson, Susan J.; Howarth, Peter J.; Thomas, Matthew J.; Adcock, Ian M.; López‐García, Carlos
- Abstract
The airway epithelium is remodelled in patients with SA and plays a pivotal role in orchestrating airway inflammation.1 However, airway epithelial cell-directed therapies have not been explored due to the lack of specific targets. CEACAM5 is an IL-13-regulated epithelial gene that mediates transcription in type-2 (T2) high severe asthma Severe asthma (SA) is a heterogeneous disease characterized by airflow restriction, frequent exacerbations and lack of effective treatments that improve quality of life and prevent exacerbations.
- Subjects
ASTHMA; DACARBAZINE; COMPUTATIONAL biology; GENES; CELL adhesion molecules; ASTHMATICS; THYROID cancer
- Publication
Allergy, 2022, Vol 77, Issue 11, p3463
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15465