We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Pretransplant Pharmacodynamic Analysis of Immunosuppressive Agents Using CFSE-Based T-Cell Proliferation Assay.
- Authors
Kurata, Y.; Kato, M.; Kuzuya, T.; Miwa, Y.; Iwasaki, K.; Haneda, M.; Amioka, K.; Watarai, Y.; Uchida, K.; Nakao, A.; Kobayashi, T.
- Abstract
The impact of pretransplant T-cell sensitivity testing using carboxylfluorescein diacetate succinimidyl ester (CFSE)–based flow cytometry was studied in 32 patients with chronic renal failure. There was considerable interindividual variation in the inhibitory effects of cyclosporine (CSA), tacrolimus (TAC), and prednisolone (PRD) but only a small amount of interindividual variation for mycophenolic acid (MPA). Patients with high sensitivity to CSA tended to experience viral reactivation. In addition to post-transplant blood-level monitoring, pretransplant pharmacodynamics could provide useful information on optimal and safe immunosuppressive therapy.
- Subjects
CYTOMETRY; CHRONIC kidney failure; IMMUNOSUPPRESSIVE agents; CYCLOSPORINE; TACROLIMUS; MYCOPHENOLIC acid; PHARMACODYNAMICS
- Publication
Clinical Pharmacology & Therapeutics, 2009, Vol 86, Issue 3, p285
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1038/clpt.2009.61