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- Title
Daily Intake of Heat-killed Lactobacillus plantarum L-137 Decreases the Probing Depth in Patients Undergoing Supportive Periodontal Therapy.
- Authors
Kazuto Iwasaki; Kenta Maeda; Kouki Hidaka; Kenji Nemoto; Yoshitaka Hirose; Shinji Deguchi; Iwasaki, Kazuto; Maeda, Kenta; Hidaka, Kouki; Nemoto, Kenji; Hirose, Yoshitaka; Deguchi, Shinji
- Abstract
<bold>Purpose: </bold>Heat-killed Lactobacillus plantarum L-137 (HK L-137) has been shown to activate innate and acquired immunity in humans. The aim of this randomised, double-blind, placebo-controlled clinical trial was to examine the effects of the oral administration of HK L-137 on the outcome of periodontal therapy.<bold>Materials and Methods: </bold>Thirty-nine patients undergoing supportive periodontal therapy (SPT) were randomly assigned to receive a capsule containing 10 mg of HK L-137 or a placebo capsule daily for 12 weeks. Nineteen patients in the experimental group and 17 patients in the control group were followed-up. Clinical parameters, including plaque index (PI), gingival index (GI), bleeding on probing (BOP), and probing depth (PD) were scored at baseline and weeks 4, 8 and 12 prior to prophylaxis in conjunction with regular SPT visits.<bold>Results: </bold>BOP and the number of teeth or sites with PD ≥ 4 mm were significantly reduced in both groups by a successive SPT programme, while there was significantly greater PD reduction (p < 0.05) at teeth with site(s) with PD ≥ 4 mm at baseline in the experimental group than in the control group at week 12.<bold>Conclusion: </bold>These clinical findings suggest that daily HK L-137 intake can decrease the depth of periodontal pockets in patients undergoing supportive periodontal therapy.
- Subjects
PERIODONTAL disease; FOOD consumption; LACTOBACILLUS plantarum; PERIODONTAL disease treatment; NATURAL immunity; CLINICAL trials; PATIENTS; PREVENTION of chronic diseases; PERIODONTITIS; PERIODONTAL pockets; THERAPEUTIC use of probiotics; COMPARATIVE studies; DENTAL prophylaxis; DENTAL scaling; LACTOBACILLUS; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PERIODONTICS; PLACEBOS; RESEARCH; TOOTH care &; hygiene; EVALUATION research; RANDOMIZED controlled trials; TREATMENT effectiveness; BLIND experiment; THERAPEUTICS; PREVENTION
- Publication
Oral Health & Preventive Dentistry, 2016, Vol 14, Issue 3, p207
- ISSN
1602-1622
- Publication type
journal article
- DOI
10.3290/j.ohpd.a36099