We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications.
- Authors
Melotte, Veerle; Xianghu Qu; Ongenaert, Maté; van Criekinge, Wim; de Bruïne, Adriaan P.; Baldwin, H. Scott; van Engeland, Manon
- Abstract
The N-myc downstream regulated gene (NDRG) family of proteins consists of 4 members, NDRG 1-4, which are well conserved through evolution. The first member to be discovered and responsible for the family name was NDRG1, because its expression is repressed by the proto-oncogenes MYCN and MYC. All family members are characterized by an α/β hydrolase-fold motif; however, the precise molecular and cellular function of these family members has not been fully elucidated. Although the exact function of NDRG family members has not been clearly elucidated, emerging evidence suggests that mutations in these genes are associated with diverse neurological and electrophysiological syndromes. In addition, aberrant expression as well as tumor suppressor and oncogenic functions affecting key hallmarks of carcinogenesis such as cell proliferation, differentiation, migration, invasion, and stress response have been reported for several of the NDRG proteins. In this review, we summarize the current literature on the NDRG family members concerning their structure, origin, and tissue distribution. In addition, we review the current knowledge regarding the regulation and signaling of the NDRG family members in development and normal physiology. Finally, their role in disease and potential clinical applications (their role as detection or prognostic markers) are discussed.
- Subjects
CELL proliferation; CELL differentiation; PROTO-oncogenes; BIOMARKERS; CANCER genetics
- Publication
FASEB Journal, 2010, Vol 24, Issue 11, p4153
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.09-151464