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- Title
Human CD4<sup>-</sup>8<sup>-</sup> T cells are a distinctive immunoregulatory subset.
- Authors
Mei-Chuan Huang; Patel, Kalpesh; Taub, Dennis D.; Longo, Dan L.; Goetzl, Edward J.
- Abstract
Human CD4-8- T cells are a minor subset quantitatively but potentially important in immunity because they are predominantly distributed at body surfaces, and their number and activities increase in autoimmune diseases and decrease with aging. Distinguishing characteristics of CD4-8- T cells are found to include a unique profile of cytokines, including Serpin E1, which is not generated by other T cells, MIF, and TGF-β. At 2-5% of the total in mixtures with CD4 + CD8 T cells, CD4-8- T cells enhance the generation of IFN-γ and IL-17 by up to 12- and 5-fold, respectively, without contributing either cytokine or affecting cytokine production by NK/NKT cells. CD4-8- T cell-derived MIF is their major enhancer and TGFβ their principal inhibitor of CD4 and CD8 T cell cytokine production. Decreases in CD4-8- T cell effects may diminish protective immunity in aging, whereas increases may augment the severity of autoimmune diseases.
- Subjects
T cells; IMMUNOREGULATION; CD4 antigen; AUTOIMMUNE diseases; AGING
- Publication
FASEB Journal, 2010, Vol 24, Issue 7, p2558
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.09-153148