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- Title
Absolute requirement of macrophages for the development and activation of [[beta]-cell cytotoxic CD8+ T-Cells in T-Cell receptor transgenic NOD mice.
- Authors
Hee-Sook Jun; Santamaria, Pere; Hye-Won Lim; Mei Luo Zhang; Ji-Won Yoon
- Abstract
Studies whether macrophages are involved in the development and/or activation of diabetogenic CD8+ T cells in autoimmune diabetes. Use of 8.3-T-cell receptor-beta transgenic NOD mice; Findings that macrophages are required for the development and activation of cytotoxic CD8+ T cellls that cause beta-cell destruction.
- Subjects
MACROPHAGES; T cells; DIABETES; AUTOIMMUNE diseases; PANCREATIC beta cells
- Publication
Diabetes, 1999, Vol 48, Issue 1, p34
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/diabetes.48.1.34