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- Title
Anti-diarrheal, anti-secretory, anti-spasmodic and antiulcer activities of Acacia modesta (Mimosaceae) aerial parts.
- Authors
Qazi, Neelam Gul; Khan, Arif-ullah; Ali, Fawad
- Abstract
Purpose: To explore the pharmacological basis for folkloric use of Acacia modesta for treating diarrhea and gastrointestinal spasm. Methods: Acacia modesta crude extract (Am.Cr) for antidiarrheal activity (100, 300 and 1000 mg/kg) was investigated in terms of reduction in diarrhea droppings in castor-oil induced diarrhea, while antisecretory activity (300 and 1000 mg/kg) was studied in castor-oil induced model in mice. Isolated rabbit jejunum tissues were employed for in vitro experiments. For antiulcer assay, ethanol-induced gastrointestinal ulcer rat model was used. Results: Am.Cr tested positive for alkaloid, tannins and flavonoids. It exhibited protective effect against castor oil-induced diarrhea and intestinal fluid accumulation in mice at 100 - 1000 mg/kg, similar to the standard drugs, loperamide and atropine respectively. In isolated tissue (rabbit jejunum), Am.Cr concentration-dependently (0.01 - 3.0 mg/mL) produced relaxation of K+ (80 mM)-induced and spontaneous contractions at concentrations to papaverine. Am.Cr significantly inhibited (p < 0.001) ethanol-induced gastric ulceration in rats. In acute toxicity testing Am.Cr did not produce any mortality up to 5 g/kg dose. Conclusion: These results show that Acacia modesta possesses anti-diarrheal, anti-secretory, antispasmodic and anti-ulcer activities, probably mediated through dual mechanisms, including Ca2+ influx and PDE enzyme(s) inhibition. The presence of phytochemicals, such as flavonoids and tannins, suggest the validity of the acclaimed ethnomedicinal effects in hyperactive gut disorders.
- Subjects
ANTIDIARRHEALS; ANTIULCER drugs; MOUSE diseases; ATROPINE; ACUTE toxicity testing
- Publication
Tropical Journal of Pharmaceutical Research, 2017, Vol 16, Issue 9, p2231
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v16i9.26