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- Title
Nasopharyngeal Carcinoma In Children And Adolescents - Long Term Follow Up From A Tertiary Cancer Center In India.
- Authors
Kaur Bajwa, Harjot; Alluri, Krishnam Raju
- Abstract
AIM: To analyse the treatment outcomes and patterns of failure of Nasopharyngeal carcinoma in children and adolescents MATERIALS & METHODS: Between Jan 2008 - Dec 2015, 37 Nasopharyngeal carcinoma patients younger than 20 yrs treated at our institution were retrospectively analysed for treatment outcomes and patterns of failure. Statistical analysis is done by two tailed Fisher's exact test RESULTS: 26 males and 11 females presented to our institution and the median age was 16 yrs (7 to 20 yrs). All patients received radical radiotherapy (64-70Gy) and 92% of patients received chemotherapy (63% patients received concurrent and adjuvant chemotherapy). 22 patients were poorly differentiated carcinoma histology and 15 undifferentiated carcinoma. There were 3(8.1%) patients in stage II, 16(43.2%) in stage III and 18(48.7%) with stage IV disease. 22% patients had N3 disease at presentation. 32 patients were included in the final analysis as 3 patients defaulted and 2 were lost to follow up. At a median follow up of 55 months (17 - 123 months), 29 patients were alive and 3 patients died of the disease. 6 patients developed distant metastasis (most common site - bone) and 2 patients had local recurrence. The Distant Metastasis Free Survival Rate was 81.25 % whereas Loco regional Control Rate was 93.75%. On statistical analysis of various factors like gender, grade, T stage, N stage and chemotherapy, the presence of N3 disease was a significant risk factor for distant metastasis (p = 0.01) CONCLUSION : Majority of the patients at our center presented with advanced disease. Chemo radiotherapy was well tolerated and achieved excellent loco regional control on long term follow up. Extensive nodal burden was a risk factor for distant metastasis.
- Subjects
INDIA; FISHER exact test; TEENAGERS; CARCINOMA; ADJUVANT treatment of cancer; FACTOR analysis
- Publication
Journal of Cancer Research & Therapeutics, 2017, Vol 13, pS170
- ISSN
0973-1482
- Publication type
Article