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- Title
Mortality in psoriatic arthritis patients, changes over time, and the impact of COVID-19: results from a multicenter Psoriatic Arthritis Registry (PsART-ID).
- Authors
Erden, Abdulsamet; Ayan, Gizem; Kilic, Levent; Solmaz, Dilek; Bakirci, Sibel; Kimyon, Gezmis; Günal, Esen Kasapoglu; Dogru, Atalay; Bayindir, Ozun; Dalkilic, Ediz; Özisler, Cem; Akar, Servet; Cetin, Gözde Yildirim; Tarhan, Emine Figen; Küçüksahin, Orhan; Omma, Ahmet; Gonullu, Emel; Yildiz, Fatih; Ersozlu, Emine Duygu; Cinar, Muhammed
- Abstract
Background: This study aimed to assess the mortality of PsA before and during the COVID-19 pandemic. Methods: From the prospective, multicenter PsART-ID (Psoriatic Arthritis Registry-International Database), patients from Turkey were analyzed by linking the registry to the Turkish Cause of Death Registry. The outcome of interest was death from any cause, pre-pandemic (since the onset of registry—March 2014–March 2020), and during the pandemic (March 2020–May 2021). The crude mortality rate and standardized mortality ratio (SMR) were determined. Results: There were 1216 PsA patients with a follow-up of 7500 patient-years. Overall, 46 deaths (26 males) were observed. In the pre-pandemic period, SMR for PsA vs the general population was 0.95 (0.61–1.49), being higher in males [1.56 (0.92–2.63)] than females [0.62 (0.33–1.17)]. The crude mortality rate in PsA doubled during the pandemic (pre-pandemic crude mortality rate: 5.07 vs 10.76 during the pandemic) with a higher increase in females (2.9 vs 8.72) than males (9.07 vs 14.73). Conclusion: The mortality in PsA was found similar to the general population in the pre-pandemic era. The mortality rates in PsA doubled during the pandemic. Whether PsA patients have more risk of mortality than the general population due to COVID-19 needs further studies. Key Points • Decrease in mortality in PsA might be expected with the more effective treatment options and better disease control. • A crude mortality rate is comparable to the general population and not increased until the pandemic. • Currently, there is a 2-fold increase in crude mortality rate possibly due to the COVID-19.
- Subjects
TURKEY; COVID-19 pandemic; COVID-19; DEATH rate; MORTALITY; DATABASES; PSORIATIC arthritis
- Publication
Clinical Rheumatology, 2023, Vol 42, Issue 2, p385
- ISSN
0770-3198
- Publication type
Article
- DOI
10.1007/s10067-022-06492-6