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- Title
Differential Degradation of the Na<sup>+</sup>/K<sup>+</sup>-ATPase Subunits in the Plasma Membrane.
- Authors
YOSHIMURA, SHIGE H.; TAKEYASU, KUNIO
- Abstract
A bstract: The cell-surface expression of the Na+/K+-ATPase is tightly regulated at the ER/Golgi transit level. The assembly of the α- and β-subunits is a prerequisite for the maturation of the enzyme and its exit from the ER. At present, the fate of the functional ATPase, once it reaches the plasma membrane, is obscure, although endocytosis, recycling, and degradation in the lysosome are known to be involved. In this study, we shall demonstrate the differential degradation of the Na+/K+-ATPase subunits in the plasma membrane: that is, lysosomal degradation of α-subunits and proteasomal degradation of β-subunits, and propose the possibility of the subunit dissociation in the plasma membrane.
- Publication
Annals of the New York Academy of Sciences, 2003, Vol 986, Issue 1, p378
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2003.tb07217.x