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- Title
Aterosclerosis carotídea e intracraneal en una población pediátrica: Un estudio de autopsia.
- Authors
Chiquete, Erwin; Valle-Rojas, Deyanira; Rodríguez-Saldaña, Joel; Rodríguez-Flores, Marcela; Aguirre-García, Jesús; Flores-Silva, Fernando; Reyes-Melo, Isael; Cantú-Brito, Carlos
- Abstract
Introduction: Limited information exists on the frequency of atherosclerosis in the very young. Objective: To describe the prevalence and severity of carotid and intracranial artery disease in subjects under the age 18 years. Methods: A prospective analysis was performed on 32 subjects aged < 18 years who underwent mandatory autopsy due to legal issues, mainly accidental deaths due to trauma. All these subjects had carotid and intracranial arteries undamaged and suitable for histopathological examination. Atheromatous plaques were graded according to the American Heart Association system (grade 0 = normal, grade I = initial lesion, grade II = fatty streak, grade III = raised fatty streak, grade IV = atheroma, grade V = fibroatheroma, grade VI = complicated lesion). Results: There were 18 (56.2%) females. Mean age was 6.5 years (median: 4.5, range: 1 to 17 years). Only eight (28.6%) subjects were older than 12 years. None of the patients had diabetes, hypertension, dyslipidemia or family history of early cardiovascular death. Only one subject had history of regular alcohol intake and smoking habit. Twenty-one (65.6%) subjects had normal carotids, four (12.5%) had grade I, and seven (21.9%) grade III lesions. The circle of Willis was normal in 19 (67.9%) subjects, one (3.6%) had grade I, six (21.4%) grade II, one (3.6%) grade IV and one (3.6%) grade V lesions. Neither complicated, nor advanced stenotic plaques were identified. Severity of atherosclerosis significantly correlated between both carotid arteries (Spearman's rho 0.569, p = 0.001), but surprisingly not with intracranial arteries. Conclusion: Incipient lesions of the atherosclerosis spectrum can be found in about 30% of intracranial and carotid arteries in very young Mexican individuals.
- Subjects
ATHEROSCLEROSIS; AUTOPSY; DISEASE prevalence; CAROTID artery diseases; HISTOPATHOLOGY; AMERICAN Heart Association
- Publication
Revista Mexicana de Neurociencia, 2012, Vol 13, Issue 2, p93
- ISSN
1665-5044
- Publication type
Article