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- Title
Gold-Catalyzed Multiple Cascade Reaction of 2-Alkynylphenylazides with Propargyl Alcohols.
- Authors
Li, Nan; Wang, Tian ‐ Yi; Gong, Liu ‐ Zhu; Zhang, Liming
- Abstract
An unprecedented gold-catalyzed multiple cascade reaction between 2-alkynyl arylazides and alkynols has been developed, allowing for the step-economical synthesis of pyrroloindolone derivatives with a wide range of structural diversity. In this reaction, the gold complex participates in triple catalysis in tandem fashion. Moreover, the efficient chirality transfer from optically pure alkynol substrates enables facile access to chiral pyrroloindolone derivatives with two stereogenic centers, including a quaternary one, with excellent levels of optical purity.
- Subjects
GOLD catalysts; PROPARGYL alcohol; YNOLS; CHEMICAL synthesis; CHEMICAL reactions; CHIRALITY
- Publication
Chemistry - A European Journal, 2015, Vol 21, Issue 9, p3585
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201406456