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- Title
Successful treatment of drug-induced acute liver failure with high-volume plasma exchange.
- Authors
Liu, Chung‐Te; Chen, Tso‐Hsiao; Cheng, Chung‐Yi
- Abstract
We report two patients with drug-induced liver injury (DILI)-related acute liver failure (ALF) who were successfully treated with high-volume plasma exchange without liver transplantation. The first patient was a 66-year-old man admitted because of a perforated duodenal ulcer complicated with peritonitis and septic shock. After treatment with multiple antibiotics, the patient developed DILI and ALF. Grade 3 hepatic encephalopathy and profound jaundice were present. Symptoms and signs of ALF improved dramatically after initiation of plasma exchange. The patient was discharged uneventfully. The second patient was a 94-year-old man admitted for treatment of newly diagnosed pulmonary tuberculosis. DILI and ALF developed 5 days after initiation of anti-tuberculosis treatment. Grade 4 hepatic encephalopathy was present. After plasma exchange, the patient's level of consciousness improved dramatically, and he recovered from ALF. These 2 cases show the potential of plasma exchange in the treatment of DILI despite occurrence acute liver failure. J. Clin. Apheresis, 28:430-434, 2013. © 2013 Wiley Periodicals, Inc.
- Publication
Journal of Clinical Apheresis, 2013, Vol 28, Issue 6, p430
- ISSN
0733-2459
- Publication type
Article
- DOI
10.1002/jca.21291