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- Title
Fast volumetric imaging of ethanol metabolism in rat liver with hyperpolarized [1-<sup>13</sup>C]pyruvate.
- Authors
Josan, Sonal; Spielman, Daniel; Yen, Yi-Fen; Hurd, Ralph; Pfefferbaum, Adolf; Mayer, Dirk
- Abstract
Rapid volumetric imaging of hyperpolarized 13C compounds allows the real-time measurement of metabolic activity and can be useful in distinguishing between normal and diseased tissues. This work extends a fast two-dimensional undersampled spiral MRSI sequence to provide volumetric coverage, acquiring a 16 × 16 × 12 matrix with a nominal isotropic resolution of 5 mm in 4.5 s. The rapid acquisition enables a high temporal resolution for dynamic imaging. This dynamic three-dimensional MRSI method was used to investigate hyperpolarized [1-13 C]pyruvate metabolism modulated by the administration of ethanol in rat liver. A significant increase in the pyruvate to lactate conversion was observed in the liver as a result of the greater availability of NADH (nicotinamide adenine dinucleotide, reduced form) from ethanol metabolism. Copyright © 2012 John Wiley & Sons, Ltd.
- Publication
NMR in Biomedicine, 2012, Vol 25, Issue 8, p993
- ISSN
0952-3480
- Publication type
Article
- DOI
10.1002/nbm.2762