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- Title
Three-year follow-up of human transplanted kidneys by diffusion-weighted MRI and blood oxygenation level-dependent imaging.
- Authors
Vermathen, Peter; Binser, Tobias; Boesch, Chris; Eisenberger, Ute; Thoeny, Harriet C.
- Abstract
Purpose: To prospectively determine the 3-year stability and potential changes of functional parameters in renal allograft recipients obtained from diffusion-weighted imaging (DWI) and blood oxygenation level-dependent (BOLD) MRI. Materials and Methods: Nine renal allograft recipients underwent DWI and BOLD-MRI twice, once 7 ± 3 months after transplantation, and again 32 ± 2 months after the first MRI. DWI yielded an apparent diffusion coefficient (ADC) and the perfusion contribution (FP). BOLD imaging yielded R2*, providing an estimation of renal oxygenation. Coefficients of variation between (CVb) and within subjects (CVw) were calculated. Results: The parameters were stable after 32 months in eight of the nine patients, who had well-functioning allografts. Mean diffusion values were very similar in the first and second scan. CVw and CVb for ADC values were less than 3.5% and 5.9%, respectively, in cortex and medulla, but were higher for FP (15%-18%). CVw and CVb of R2* were also low (medulla: CVw = 10.8%, CVb = 11.4%; cortex: CVw and CVb = 7.2%). R2* increased significantly ( P = 0.035) in cortex but not in medulla, suggesting reduced cortical oxygen content. One subject with decreased glomerular filtration rate demonstrated strongly altered parameters. Conclusion: In the absence of graft dysfunction, DWI and BOLD imaging yield consistent results over 3 years in stable human renal allograft recipients. J. Magn. Reson. Imaging 2012;. © 2011 Wiley Periodicals, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2012, Vol 35, Issue 5, p1133
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.23537