We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Distribution of cardiac iron measured by magnetic resonance imaging (MRI)-R*<sub>2</sub>.
- Authors
Yamamura, Jin; Grosse, Regine; Graessner, Joachim; Janka, Gritta E.; Adam, Gerhard; Fischer, Roland
- Abstract
Purpose To assess regional iron distribution by magnetic resonance imaging (MRI)-R2* within the heart of patients with β-thalassemia major (TM) and other iron overload diseases. Materials and Methods Breathhold electrocardiogram (ECG)-gated MRI (1.5 T) of the heart was used for the measurement of transverse relaxation rates R2* in 32 patients (11-79 years). In a mid-papillary short-axis slice divided into septal, anterior, lateral, and posterior quadrants, R2* was analyzed from region of interest (ROI)-based signal intensities from 12 echo times (TE = 1.3-26 msec). Typical boundary effects were evaluated in detail. Results The segmentation of the cardiac wall resulted in highly significant correlations of R2* between septal and all other quadrants. In the patient group with R2* < 50 s−1 (normal), all quadrants show higher normalized median rates (126%-174%) than the septum ( P < 10−4), while this was relatively smaller in the group with septal R2* > 50 s−1. Typical boundary effects on segmental R2* from blood, lung tissue, epicardial fat, and hepatic iron could not be easily separated from segmental iron distribution. Conclusion The measurement of MRI-R2* in the interventricular septum is the least affected method by boundary effects to detect patients with iron overload at risk of developing heart failure. J. Magn. Reson. Imaging 2010;32:1104-1109. © 2010 Wiley-Liss, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2010, Vol 32, Issue 5, p1104
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.22364