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- Title
Evolution of hyperacute stroke over 6 hours using serial MR perfusion and diffusion maps.
- Authors
Harris, Ashley D.; Kosior, Robert K.; Chen, Henry S.; Andersen, Linda B.; Frayne, Richard
- Abstract
Purpose To develop an appropriate method to evaluate the time-course of diffusion and perfusion changes in a clinically relevant animal model of ischemic stroke and to examine lesion progression on MR images. An exploration of acute stroke infarct expansion was performed in this study by using a new methodology for developing time-to-infarct maps based on the time at which each voxel becomes infarcted. This enabled definition of homogeneous regions from the heterogeneous stroke infarct. Materials and Methods Time-to-infarct maps were developed based on apparent diffusion coefficient (ADC) changes. These maps were validated and then applied to blood flow and time-to-peak maps to examine perfusion changes. Results ADC stroke infarct showed different evolution patterns depending on the time at which that region of tissue infarcted. Applying the time-to-infarct maps to the perfusion maps showed localized perfusion evolution characteristics. In some regions, perfusion was immediately affected and showed little change over the experiment; however, in some regions perfusion changes were more dynamic. Conclusion Results were consistent with the diffusion-perfusion mismatch hypothesis. In addition, characteristics of collateral recruitment were identified, which has interesting stroke pathophysiology and treatment implications. J. Magn. Reson. Imaging 2009;29:1262-1270. © 2009 Wiley-Liss, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2009, Vol 29, Issue 6, p1262
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.21763