We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
C4-Alkylamination of C4-Halo-1 H -1-tritylpyrazoles Using Pd(dba) 2 or CuI.
- Authors
Usami, Yoshihide; Tatsui, Yuya; Yoneyama, Hiroki; Harusawa, Shinya; Silva, Vera L. M.; Silva, Artur M. S.
- Abstract
Alkylamino coupling reactions at the C4 positions of 4-halo-1H-1-tritylpyrazoles were investigated using palladium or copper catalysts. The Pd(dba)2 catalyzed C-N coupling reaction of aryl- or alkylamines, lacking a β-hydrogen atom, proceeded smoothly using tBuDavePhos as a ligand. As a substrate, 4-Bromo-1-tritylpyrazole was more effective than 4-iodo or chloro-1-tritylpyrazoles. Meanwhile, the CuI mediated C-N coupling reactions of 4-iodo-1H-1-tritylpyrazole were effective for alkylamines possessing a β-hydrogen atom.
- Subjects
PALLADIUM; COPPER catalysts; ALIPHATIC amines
- Publication
Molecules, 2020, Vol 25, Issue 20, p4634
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25204634