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- Title
Studies on the Anticonvulsant Activity and Influence on GABA-ergic Neurotransmission of 1,2,4-Triazole-3-thione-Based Compounds.
- Authors
Plech, Tomasz; Kaproń, Barbara; Łuszczki, Jarogniew J.; Wujec, Monika; Paneth, Agata; Siwek, Agata; Kołaczkowski, Marcin; Żołnierek, Maria; Nowak, Gabriel
- Abstract
The anticonvulsant activity of several 1,2,4-triazole-3-thione derivatives on mouse maximal electroshock-induced seizures was tested in this study. Characteristic features of all active compounds were rapid onset of action and long lasting effect. Structure-activity observations showed that the probability of obtaining compounds exerting anticonvulsant activity was much higher when at least one of the phenyl rings attached to 1,2,4-triazole nucleus had a substituent at the para position. The obtained results, moreover, permit us to conclude that despite the structural similarity of loreclezole (second-generation anticonvulsant drug) and the titled compounds, their anticonvulsant activity is achieved via completely different molecular mechanisms.
- Subjects
TRIAZOLES; MANNICH bases; SPASMS; BLOOD-brain barrier; RADIOLIGAND assay; DIAGNOSIS
- Publication
Molecules, 2014, Vol 19, Issue 8, p11279
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules190811279