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- Title
Synthesis and Anti-Hyperlipidemic Evaluation of N-(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats.
- Authors
Shattat, Ghassan; Al-Qirim, Rania; Al-Hiari, Yusuf; Sheikha, Ghassan Abu; Al-Qirim, Tariq; El-Huneidi, Waseem; Shahwan, Moyad
- Abstract
The lipid-lowering activity of a series of novel N-(benzoylphenyl)-5-fluoro-1Hindole-2-carboxamide derivatives has been studied in Triton WR-1339-induced hyperlipidemia in rats. The test animals were divided into four groups: control, hyperlipidemic, compound + 4% DMSO [C1: N-(2-benzoylphenyl)-5-fluoro-1H-indole-2- carboxamide (1), C2: N-(3-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (2), C3: N- (4-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (3)]-treated and bezafibrate (BF)- treated. At a dose of 15 mg/Kg body weight, compounds 2, 3 and BF significantly reduced elevated plasma triglycerodes levels after 12 h. Moreover, high density lipoproteincholesterol levels were significantly increased in all treated groups after 12 h compared to the hyperlipidemic control group, except for C1 which was inactive. In sum, it may be stated that the results of the present study demonstrated new properties of some N- (benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives as potent lipid lowering agents and these beneficial activities may contribute to their cardioprotective and antiatherosclerotic role.
- Subjects
LIPIDS; LABORATORY rats; BODY weight; CHOLESTEROL; HIGH density lipoproteins
- Publication
Molecules, 2010, Vol 15, Issue 9, p5840
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules15095840