We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Influence of Serotonin on the Human Ureter: An in vitro Pharmacological Study.
- Authors
Gidener, Sedef; Kirkali, Ziya; Güven, Hülya
- Abstract
The influence of serotonin (5-hydroxytryptamine, 5-HT) on human ureteral smooth muscle was explored in a series of in vitro experiments. 5-HT evoked a dose-dependent contraction of the ureter. The effect of 5-HT was unaltered by blockade of 5HT3 and 5HT4 receptors and muscarinic cholinergic receptors. The 5HT2 receptor antagonist ketanserin (KT; 10--5-10--4M) and mixed 5HT1/5HT2 receptor antagonist methysergide (MS; 5 × 10--5M) inhibited the effect of 5-HT. Since the antagonist dissociation constant at 5HT2 receptors for both KT and MS is found to be approximately 10--9M, it is concluded that this contractile effect may have been mediated by some other, as yet uncharac-terized 5-HT receptor. We believe that 5-HT is a potential neurotransmitter in the human upper ureteral smooth muscle. Copyright © 1995 S. Karger AG, Basel
- Publication
Urologia Internationalis, 1995, Vol 55, Issue 4, p202
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000282786