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- Title
Content of Carbonyl Compounds and Parameters of Glutathione Metabolism in Men with Type 1 Diabetes Mellitus at Preclinical Stages of Diabetic Nephropathy.
- Authors
Darenskaya, M. A.; Chugunova, E. V.; Kolesnikov, S. I.; Grebenkina, L. A.; Semenova, N. V.; Nikitina, O. A.; Kolesnikova, L. I.
- Abstract
The content of carbonyl compounds (methylglyoxal and TBA-reactive substances) and components of the glutathione system (activities of glutathione-dependent enzymes, content of oxidized and reduced glutathione) and their interrelationships were studied in men of young reproductive age with type 1 diabetes mellitus at the stages of normo- and microalbuminuria. In patients with normoalbuminuria, the level of methylglyoxal, reduced and oxidized glutathione, and glutathione reductase activity were increased and the content of TBA-reactive substances was decreased. In the group with microalbuminuria, an increase in content of methylglyoxal and activity of glutathione-dependent enzymes relative to the control values were observed; the content of TBA-reactive substances was increased and glutathione reductase activity was decreased relative to the group with normoalbuminuria. In patients with microalbuminuria, a strong correlation between the mean glomerular filtration rate and the blood level of methylglyoxal was revealed.
- Subjects
TYPE 1 diabetes; DIABETIC nephropathies; CARBONYL compounds; GLUTATHIONE reductase; GLUTATHIONE; GLOMERULAR filtration rate; CREATININE
- Publication
Bulletin of Experimental Biology & Medicine, 2021, Vol 171, Issue 5, p592
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-021-05275-4