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- Title
Prevalence of Methotrexate Toxicity and Intolerance in Juvenile Idiopathic Arthritis and Possible Risk Factors for Methotrexate Intolerance: A Tertiary Center Experience.
- Authors
Tekin, Zahide Ekici; Kaplan, Melike Mehveş; Polat, Merve Cansu; Çelikel, Elif; Güngörer, Vildan; Kurt, Tuba; Tekgöz, Nilüfer; Sezer, Müge; Karagöl, Cüneyt; Coşkun, Serkan; Öner, Nimet; Acar, Banu Çelikel
- Abstract
Methotrexate has a safe and inexpensive profile and is the first choice of juvenile idiopathic arthritis treatment. Nevertheless, gastrointestinal symptoms are not serious but are common side effects of methotrexate. Sometimes patients may have nausea by thinking of methotrexate and even refuse methotrexate use. In this study, we aimed to define the prevalence of methotrexate side effects in juvenile idiopathic arthritis and the possible risk factors for methotrexate intolerance. Methotrexate intolerance severity score showed a severity of gastrointestinal symptoms. Eighty-seven patients accepted to join the study and answered the questions. The prevalence of adverse events of methotrexate was 64.4% and the rate of gastrointestinal symptoms was 55.2%. Nausea (27.6%) was the most common gastrointestinal symptom. The median methotrexate intolerance severity score was 14.5 (interquartile range: 10-18). However, there was no significant difference in main parameters between tolerant and intolerant groups and no risk factor was observed for methotrexate intolerance. In a conclusion, we observed methotrexate toxicity and intolerance commonly but no associative factors were defined, and, prospective larger studies are necessary to understand and prevent the occurrence of gastrointestinal symptoms.
- Subjects
METHOTREXATE; JUVENILE idiopathic arthritis; DISEASE risk factors; DRUG side effects; NAUSEA
- Publication
Journal of Pediatric Academy (J. Pediatr. Acad.), 2022, Vol 3, Issue 2, p60
- ISSN
2718-0875
- Publication type
Article
- DOI
10.51271/jpea-2022-184