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- Title
Inflammatory myopathy associated with statins: report of three cases.
- Authors
Kuncova, Klara; Sedlackova, Marie; Vencovsky, Jiri; Mann, Herman; Tomcik, Michal; Wenchich, Laszlo; Zamecnik, Josef
- Abstract
Statins are well-established lipid-lowering drugs that reduce morbidity and mortality due to cardiovascular disease and cause adverse effects relatively rarely. It is still unclear whether statins are capable of inducing an immune-mediated response directed against skeletal muscle. Here, we present the cases of three patients who developed inflammatory myopathy in the course of statin treatment. Moreover, multiple mitochondrial DNA deletions were found in two of them. The ability of statins to induce an immune-mediated response and their interactions with mitochondrial metabolism pathways are discussed.
- Subjects
INFLAMMATION; MUSCLE diseases; STATINS (Cardiovascular agents); ANTILIPEMIC agents; CARDIOVASCULAR diseases; ADVERSE health care events; IMMUNE response; MITOCHONDRIAL DNA
- Publication
Modern Rheumatology, 2014, Vol 24, Issue 2, p366
- ISSN
1439-7595
- Publication type
Article
- DOI
10.3109/14397595.2013.852848