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- Title
Polyethylene Glycol and Polysorbate 80 Skin Tests in the Context of an Allergic Risk Assessment for Hypersensitivity Reactions to Anti-SARS-CoV-2 mRNA Vaccines.
- Authors
Nappi, Emanuele; Racca, Francesca; Piona, Alessandra; Messina, Maria Rita; Ferri, Sebastian; Lamacchia, Donatella; Cataldo, Giuseppe; Costanzo, Giovanni; Del Moro, Lorenzo; Puggioni, Francesca; Canonica, Giorgio Walter; Heffler, Enrico; Paoletti, Giovanni
- Abstract
Concern has arisen about hypersensitivity reactions in patients with allergic reactions to drugs containing polyethylene glycol (PEG) or polysorbate 80 (PS80), excipients of currently available anti-SARS-CoV-2 mRNA vaccines. However, the actual utility of PEG and PS80 skin allergy testing is currently still debated. We retrospectively analyzed all cases of patients on whom we performed allergometric skin tests for PEG and PS80 in the context of a pre-vaccination screening (for patients with multiple hypersensitivity reactions to drugs for which these excipients were among the suspected agents) or following suspected hypersensitivity reactions to anti-SARS-CoV-2 vaccines. A total of 134 tests were performed for PEG and PS80, eight of which produced uninterpretable results (due to dermographism or non-specific reactions). Of the remaining 126 cases (85 pre-vaccinal and 41 post-vaccine reactions), 16 (12.7%) were positive for PEG and/or PS80. Stratifying by clinical indication, there were no statistically significant differences in the proportion of positive tests between patients evaluated in the context of the pre-vaccination screening and those evaluated after a vaccine reaction (10.6% vs. 17.1%, respectively, p = 0.306). Allergometric skin tests for PEG and PS80 in our case series resulted positive in an unexpectedly high proportion of patients, suggesting that testing for allergy to these two excipients should not be ignored in case of reasonable clinical suspicion.
- Subjects
POLYSORBATE 80; SKIN tests; POLYETHYLENE glycol; RISK assessment; ALLERGIES; HEPATITIS B
- Publication
Vaccines, 2023, Vol 11, Issue 5, p915
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines11050915