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- Title
Genetische und immungenetische Aspekte der Narkolepsie.
- Authors
Mayer, G.; Lattermann, A.; Meier-Ewert, K.; Mueller-Eckhardt, Gertrud
- Abstract
Narcolepsy is the disease with the strongest HLA association. Only very few patients were found to be negative for the “typical” alleles DRB1*1501 (DR15(2)) and/or DQB1*0602 (DQ6(1)). Ethnical differences exist concerning narcolepsy-linked HLA-haplotypes in patients and in normal populations. Therefore, the interpretation of immunogenetic data with respect to narcolepsy widely depends on exact classification of the disease including the use of sleep latency tests and standardised questionnaires such as the “Stanford Center of Narcolepsy Sleep Inventory”. Comparison of immunogenetic data from Japanese, Caucasian and Afro-American narcolepsy patients have shown that HLA association with narcolepsy is rather located in the DQ (*0602) than in the DR (*1501) region. In multicase families, a unique mode of inheritance of a “disease susceptibility gene” could not be verified. Patients within multiplex families were DRB1*1501 negative in 21–35%. The same was true for 3 monozygotic twins concordant for narcolepsy. The probability for first degree relatives of narcoleptic patients to become narcoleptic is 40-fold, for members of multicase families even almost 700-fold as compared with the normal population. From this data it can be concluded that, in addition to the HLA system, other genetic and/or non-genetic factors may play a role in the pathogenesis of narcolepsy.
- Publication
Somnologie, 1997, Vol 1, Issue 3, p126
- ISSN
1432-9123
- Publication type
Article
- DOI
10.1007/s11818-997-0023-3