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- Title
Novel genetic basis of field-evolved resistance to Bt toxins inPlutella xylostella.
- Authors
Baxter, S. W.; Zhao, J.-Z.; Gahan, L. J.; Shelton, A. M.; Tabashnik, B. E.; Heckel, D. G.
- Abstract
Insecticidal toxins fromBacillus thuringiensis(Bt) are widely used to control pest insects, but evolution of resistance threatens their continued efficacy. The most common type of Bt resistance (‘Mode 1’) is characterized by recessive inheritance, > 500-fold resistance to at least one Cry1A toxin, negligible cross-resistance to Cry1C, and reduced binding of Bt toxins to midgut membrane target sites. Mutations affecting a Cry1A-binding midgut cadherin protein are linked to laboratory-selected Mode 1 resistance inHeliothis virescensandPectinophora gossypiella. Here we show that field-evolved Mode 1 resistance in the diamondback moth,Plutella xylostella, has a different genetic basis, indicating that screening for resistance in the field should not be restricted to a previously proposed DNA-based search for cadherin mutations.
- Subjects
PLUTELLA; YPONOMEUTIDAE; DRUG resistance in microorganisms; TOXINS; ANIMAL genetics; GENETICS
- Publication
Insect Molecular Biology, 2005, Vol 14, Issue 3, p327
- ISSN
0962-1075
- Publication type
Article
- DOI
10.1111/j.1365-2583.2005.00563.x