We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Leucocytoclastic vasculitis associated with mixed cryoglobulinaemia and hepatitis C virus infection.
- Authors
Abe, Y.; Tanaka, Y.; Takenaka, M.; Yoshida, H.; Yatsuhashi, H.; Yano, M.
- Abstract
Mixed cryoglobulinaemia is frequently associated with chronic hepatitis. We report a patient with mixed cryoglobulinaemia, hepatitis C virus (HCV) infection and palpable purpura. The skin manifestations were diagnosed as leucocytoclastic vasculitis in view of both the clinical appearance and the histological findings. In this study, we demonstrated the presence of IgG-class anti-HCV-antibody, HCV-RNA and IgA-class rheumatoid factor in the cryoprecipitate. These results suggest that the cryoglobulinaemia in this case was caused by aggregation of an immune complex comprised of HCV and anti-HCV antibody with IgA-type-rheumatoid factor, and that this led to a cutaneous vasculitis.
- Subjects
CUTANEOUS manifestations of general diseases; SKIN diseases; CRYOGLOBULINEMIA; HEPATITIS C virus; VASCULITIS; DERMATOLOGY; MEDICAL research
- Publication
British Journal of Dermatology, 1997, Vol 136, Issue 2, p272
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1997.tb14913.x