We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype.
- Authors
Miyagawa, Taku; Honda, Makoto; Kawashima, Minae; Shimada, Mihoko; Tanaka, Susumu; Honda, Yutaka; Tokunaga, Katsushi
- Abstract
Essential hypersomnia (EHS) exhibits excessive daytime sleepiness without cataplexy and is associated with the HLA-DRB1*1501-DQB1*0602 haplotype, similar to narcolepsy with cataplexy. Single-nucleotide polymorphism (SNP) rs1154155 located in the T-cell receptor α (TCRA) locus has been recently identified as a novel genetic marker of susceptibility for narcolepsy with cataplexy. We investigated whether the SNP was associated with EHS in the Japanese population. We found a significant association with EHS patients possessing the HLA-DRB1*1501-DQB1*0602 haplotype, compared with HLA-matched healthy individuals (Pallele=0.008; Ppositivity=5 × 10−4), whereas no significant association was observed for EHS patients without this haplotype. Thus, TCRA is a plausible candidate for susceptibility to EHS patients positive for the HLA-DRB1*1501-DQB1*0602 haplotype.
- Subjects
HYPERSOMNIA; HLA histocompatibility antigens; NARCOLEPSY; T cell receptors; DROWSINESS
- Publication
Journal of Human Genetics, 2010, Vol 55, Issue 1, p63
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1038/jhg.2009.118