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- Title
Previously Unreported Chromosomal Aberrations of t(3;3)(q29;q23), t(4;11)(q21;q23), and t(11;18)(q10;q10) in a Patient with Accelerated Phase Ph+ CML.
- Authors
Aydin, Cigdem; Cetin, Zafer; Salim, Ozan; Yucel, Orhan Kemal; Undar, Levent; Karauzum, Sibel Berker
- Abstract
Chronic myelogenous leukemia (CML) is a clonal hematological disorder, which is characterized by the presence of the classical or variant Philadelphia translocations. During the progression to blastic phase of the disease secondary chromosomal abnormalities may emerge. Such secondary chromosomal abnormalities are nonrandom, the more frequent ones being trisomy 8 and 19, supernumerary i(17q), and extra Philadelphia chromosomes. Furthermore, a minor percentage of the patients may acquire different secondary chromosomal abnormalities including translocations between other chromosomes. We report here a patient with Ph+ CML presenting secondary chromosomal abnormalities including t(4;11)(q21;q23), t(3;3)(q29;q23) and t(11;18)(q10;q10) during the course of CML progression.
- Subjects
CHROMOSOME abnormalities; CHRONIC myeloid leukemia; HEMATOLOGIC malignancies; CHROMOSOMAL translocation; HUMAN chromosome abnormalities
- Publication
Case Reports in Genetics, 2014, p1
- ISSN
2090-6544
- Publication type
Case Study
- DOI
10.1155/2014/582016