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- Title
Case-Control Study of Clostridium innocuum Infection, Taiwan.
- Authors
Yi-Ching Chen; Yi-Chun Kuo; Mi-Chi Chen; Young-Da Zhang; Chyi-Liang Chen; Puo-Hsien Le; Cheng-Hsun Chiu; Chen, Yi-Ching; Kuo, Yi-Chun; Chen, Mi-Chi; Zhang, Young-Da; Chen, Chyi-Liang; Le, Puo-Hsien; Chiu, Cheng-Hsun
- Abstract
Vancomycin-resistant Clostridium innocuum was recently identified as an etiologic agent for antibiotic-associated diarrhea in humans. We conducted a case-control study involving 152 C. innocuum-infected patients during 2014-2019 in Taiwan, using 304 cases of Clostridioides difficile infection (CDI) matched by diagnosis year, age (+2 years), and sex as controls. The baseline characteristics were similar between the 2 groups. C. innocuum-infected patients experienced more extraintestinal clostridial infection and gastrointestinal tract-related complications than did patients with CDI. The 30-day mortality rate among C. innocuum-infected patients was 14.5%, and the overall rate was 23.0%. Chronic kidney disease, solid tumor, intensive care unit admission, and shock status were 4 independent risk factors for death. C. innocuum identified from clinical specimens should be recognized as a pathogen requiring treatment, and because of its intrinsic vancomycin resistance, precise identification is necessary to guide appropriate and timely antimicrobial therapy.
- Subjects
TAIWAN; CLOSTRIDIOIDES difficile; VANCOMYCIN resistance; CASE-control method; CLOSTRIDIUM diseases; CHRONIC kidney failure; INTENSIVE care units; ENTEROCOCCAL infections; ANTIBIOTICS; RESEARCH; EVALUATION research; COMPARATIVE studies
- Publication
Emerging Infectious Diseases, 2022, Vol 28, Issue 3, p599
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/2803.204421