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- Title
The impact of 2015 neuromyelitis optica spectrum disorders criteria on diagnostic rates.
- Authors
Hamid, Shahd H. M.; Elsone, Liene; Mutch, Kerry; Solomon, Tom; Jacob, Anu
- Abstract
Background: The international panel for neuromyelitis optica (NMO) diagnosis has proposed diagnostic criteria for neuromyelitis optica spectrum disorders (NMOSD). Objectives: We assessed the impact of these criteria on diagnostic rates in a large cohort of patients. Methods: We identified and applied the 2006 and 2015 criteria to all patients (n = 176) seen in the NMO and non-multiple sclerosis central nervous system demyelination clinic (part of the UK NMO service) from January 2013 to May 2015. Results: The 2006 criteria classified 63 of 176 (36%) patients as NMO. A total of 42 patients (67%) were aquaporin 4 (AQP4) immunoglobulin G (IgG) +ve and 21 (33%) AQP4 IgG −ve. The 2015 criteria classified 111 of 176 (63%) patients as NMOSD, of which 81 (73%) were AQP4 IgG +ve and 30 (27%) were AQP4 IgG −ve. There was an increase of 48 patients (76%) diagnosed as NMOSD using the new criteria. Conclusion: Application of the 2015 criteria led to a rise in diagnosis of NMOSD by 76%. The rise in the AQP4 IgG +ve group contributed 62% and the seronegative group contributed 14%.
- Subjects
NEUROMYELITIS optica; CNS demyelinating autoimmune diseases; MULTIPLE sclerosis; MYELIN sheath diseases; OPTIC neuritis; DIAGNOSIS
- Publication
Multiple Sclerosis Journal, 2017, Vol 23, Issue 2, p228
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458516663853