We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Predicting Mood Disturbance Severity with Mobile Phone Keystroke Metadata: A BiAffect Digital Phenotyping Study.
- Authors
Zulueta, John; Piscitello, Andrea; Rasic, Mladen; Easter, Rebecca; Babu, Pallavi; Langenecker, Scott A.; McInnis, Melvin; Ajilore, Olusola; Nelson, Peter C.; Ryan, Kelly; Leow, Alex
- Abstract
<bold>Background: </bold>Mood disorders are common and associated with significant morbidity and mortality. Better tools are needed for their diagnosis and treatment. Deeper phenotypic understanding of these disorders is integral to the development of such tools. This study is the first effort to use passively collected mobile phone keyboard activity to build deep digital phenotypes of depression and mania.<bold>Objective: </bold>The objective of our study was to investigate the relationship between mobile phone keyboard activity and mood disturbance in subjects with bipolar disorders and to demonstrate the feasibility of using passively collected mobile phone keyboard metadata features to predict manic and depressive signs and symptoms as measured via clinician-administered rating scales.<bold>Methods: </bold>Using a within-subject design of 8 weeks, subjects were provided a mobile phone loaded with a customized keyboard that passively collected keystroke metadata. Subjects were administered the Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS) weekly. Linear mixed-effects models were created to predict HDRS and YMRS scores. The total number of keystrokes was 626,641, with a weekly average of 9791 (7861), and that of accelerometer readings was 6,660,890, with a weekly average 104,076 (68,912).<bold>Results: </bold>A statistically significant mixed-effects regression model for the prediction of HDRS-17 item scores was created: conditional R2=.63, P=.01. A mixed-effects regression model for YMRS scores showed the variance accounted for by random effect was zero, and so an ordinary least squares linear regression model was created: R2=.34, P=.001. Multiple significant variables were demonstrated for each measure.<bold>Conclusions: </bold>Mood states in bipolar disorder appear to correlate with specific changes in mobile phone usage. The creation of these models provides evidence for the feasibility of using passively collected keyboard metadata to detect and monitor mood disturbances.
- Subjects
MOBILE health; BIPOLAR disorder; MENTAL depression; MANIA; CELL phones; RESEARCH; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; PSYCHOLOGICAL tests; AFFECTIVE disorders; HAMILTON Depression Inventory; PHENOTYPES; LONGITUDINAL method
- Publication
Journal of Medical Internet Research, 2018, Vol 20, Issue 7, p122
- ISSN
1439-4456
- Publication type
journal article
- DOI
10.2196/jmir.9775