We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis.
- Authors
Fabrizio Veglia; Steffen Loft; Giuseppe Matullo; Marco Peluso; Armelle Munnia; Frederica Perera; David H. Phillips; Deliang Tang; Herman Autrup; Ole Raaschou-Nielsen; Anne Tjønneland; Paolo Vineis; for the GenairâEPIC investigators
- Abstract
Bulky DNA adducts are biomarkers of exposure to aromatic compounds and of the ability of the individual to metabolically activate carcinogens and to repair DNA damage. Their ability to predict cancer onset is uncertain. We have performed a pooled analysis of three prospective studies on cancer risk in which bulky DNA adducts have been measured in blood samples collected from healthy subjects (N = 1947; average follow-up 51â137 months). In addition, we have performed a meta-analysis by identifying all articles on the same subject published up to the end of 2006, including caseâcontrol studies. In the pooled analysis, a weakly statistically significant increase in the risk of lung cancer was apparent (14% per unit standard deviation change in adduct levels, 95% confidence interval 1â28%; using the weighted mean difference method, 0.15 SD, units higher adducts in cases than in controls). The association was evident only in current smokers and was absent in former smokers. Also the meta-analysis, which included both lung and bladder cancers, showed a statistically significant association in current smokers, whereas the results in never smokers were equivocal; in former smokers, no association was detected. The results of our pooled and meta-analyses suggest that bulky DNA adducts are associated with lung cancer arising in current smokers after a follow-up of several years.
- Subjects
DNA; AROMATIC compounds; BIOCHEMICAL genetics; LUNG cancer
- Publication
Carcinogenesis, 2008, Vol 29, Issue 5, p932
- ISSN
0143-3334
- Publication type
Article