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- Title
Bacterial capture efficiency in fluid bloodstream improved by bendable nanowires.
- Authors
Lizhi Liu; Sheng Chen; Zhenjie Xue; Zhen Zhang; Xuezhi Qiao; Zongxiu Nie; Dong Han; Jianlong Wang; Tie Wang
- Abstract
Bacterial infectious diseases, such as sepsis, can lead to impaired function in the lungs, kidneys, and other vital organs. Although established technologies have been designed for the extracorporeal removal of bacteria, a high flow velocity of the true bloodstream might result in low capture efficiency and prevent the realization of their full clinical potential. Here, we develop a dialyzer made by three-dimensional carbon foam pre-grafted with nanowires to isolate bacteria from unprocessed blood. The tip region of polycrystalline nanowires is bent readily to form three-dimensional nanoclaws when dragged by the molecular force of ligandreceptor, because of a decreasing Young’s moduli from the bottom to the tip. The bacterial capture efficiency was improved from ~10% on carbon foam and ~40% on unbendable singlecrystalline nanowires/carbon foam to 97% on bendable polycrystalline nanowires/carbon foam in a fluid bloodstream of 10 cm s−1 velocity.
- Subjects
CARBON foams; YOUNG'S modulus; SILICON nanowires; FLOW velocity; DRAG force; BACTERIAL diseases; NANOWIRES
- Publication
Nature Communications, 2018, Vol 9, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-018-02879-9