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- Title
Synthesis and Antibreast Cancer Activity Testing of Some N-Arylidene-4-Phenyl-1H-Pyrazol-3-Amine Derivatives.
- Authors
Karthikeyan, C.; Tiwari, P.; Tiwari, A. K.; Trivedi, P.
- Abstract
Breast cancer is one of the most commonly diagnosed cancers among women and it is the second leading cause of cancer deaths in women worldwide. The present study describes the synthesis and cytotoxic activity testing of a series of N-arylidene-4-phenyl-1H-pyrazol-3-amine derivatives (3a-3s) as potential antibreast cancer agents. Ninteen derivatives synthesized were tested for cytotoxicity against one breast cancer cell line (MCF-7) and one normal cell line (MDCK). The MTT assay results indicated that compound 3p with 2-chloro substitution in the phenyl ring linked to the amino group of 4-phenyl-1H-pyrazol-3-amine moiety showed promising anticancer activity (66.4 μM) against the studied MCF-7 cell line. Furthermore, the compound did not show any significant cytotoxicity (> 100 μM) against normal cell line making it a selective cytotoxic agent. Overall, the findings of the present research highlight 3p as a potential new lead molecule for the development of novel anticancer agents with therapeutic benefits in breast cancer.
- Subjects
BREAST cancer treatment; ANTINEOPLASTIC agents; PYRAZOLES; AMINE derivatives; CELL lines
- Publication
International Journal of Pharmacy & Life Sciences, 2017, Vol 8, Issue 5, p22
- ISSN
0976-7126
- Publication type
Article