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- Title
Formulation and Evaluation of Acamprosate Calcium Implant using Poly (Lactic-co-glycolic acid).
- Authors
Patil, P. R.; Wagh, M. P.; Chaudhari, S. R.
- Abstract
This present research study was carried out to develop and evaluate the implants of Acamprosate calcium by using biodegradable polymeric material PLGA. Acamprosate calcium is commonly used in treatment of alcoholism as abuse deterrent. Implants were prepared by using PLGA as polymer and magnesium stearate as a plasticizer under controlled environment. The implants, weighing approximately 180 mg were evaluated for thickness, hardness, friability, weight variation, drug content uniformity and drug polymer interaction. In vitro drug release studies were conducted in phosphate buffer pH 7.4.
- Subjects
GLYCOLIC acid; POLYLACTIC acid; ACAMPROSATE calcium; ALCOHOLISM treatment; BUFFER solutions
- Publication
International Journal of Pharmacy & Life Sciences, 2016, Vol 7, Issue 4, p4972
- ISSN
0976-7126
- Publication type
Article