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- Title
Advances in therapeutic applications of extracellular vesicles.
- Authors
Wiklander, Oscar P. B.; Brennan, Meadhbh Á.; Lötvall, Jan; Breakefield, Xandra O.; EL Andaloussi, Samir
- Abstract
Understanding extracellular vesicle biology and production will pave the way for a new type of biotherapeutic. Extracellular vesicles (EVs) are nanometer-sized, lipid membrane–enclosed vesicles secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid species of the source cell. EVs act as important mediators of intercellular communication that influence both physiological and pathological conditions. Given their ability to transfer bioactive components and surmount biological barriers, EVs are increasingly being explored as potential therapeutic agents. EVs can potentiate tissue regeneration, participate in immune modulation, and function as potential alternatives to stem cell therapy, and bioengineered EVs can act as delivery vehicles for therapeutic agents. Here, we cover recent approaches and advances of EV-based therapies.
- Subjects
LIPIDS; BIOACTIVE compounds; PATHOLOGY; VESICLES (Cytology); NUCLEIC acids
- Publication
Science Translational Medicine, 2019, Vol 11, Issue 492, pN.PAG
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aav8521