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- Title
Application of a point of care creatinine device for trend monitoring in kidney transplant patients: fit for purpose?
- Authors
van Lint, Céline L.; van der Boog, Paul J. M.; Romijn, Fred P. H. T. M.; Schenk, Paul W.; van Dijk, Sandra; Rövekamp, Ton J. M.; Kessler, Anja; Siekmann, Lothar; Rabelink, Ton J.; Cobbaert, Christa M.
- Abstract
Background: The StatSensor® Xpress-i™, a point-of-care system for blood creatinine measurement, offers patients the possibility of self-monitoring creatinine. In this study, the analytical performance of the StatSensor® for both detecting current renal function and monitoring renal (dys)function in kidney transplant patients was examined. Methods: Accuracy of the StatSensor® with capillary and venous whole blood was evaluated and compared to an isotopic dilution mass spectrometry (IDMS)-traceable enzymatic creatinine test in venous serum (n = 138). Twenty Li-heparin samples were compared to the IDMS reference method performed by a Joint Committee for Traceability in Laboratory Medicine (JCTLM)-listed reference laboratory (RfB, Bonn, Germany). To evaluate StatSensor®'s suitability to monitor kidney function, both venous and capillary samples were obtained in 20 hospitalized transplantation patients. Venous samples were analyzed with an IDMS-traceable enzymatic test, capillary samples were measured using the StatSensor®. For all 2-day intervals, percentage change in creatinine was compared between both methods. Results: The StatSensor® did not meet total allowable error criterion of 6.9%. Average overall CVa for the StatSensor® was 10.4% and 5.2% for capillary and venous whole blood results, respectively. Overall CVa for the central laboratory serum creatinine method was < 1.5%. For monitoring renal (dys)function, total agreement of the StatSensor® with an IDMS-traceable enzymatic test was 68% using a 10% Δ change. No significant differences were found between the changes observed by both methods. Conclusions: Capillary blood testing with the StatSensor® is not advisable for determining current renal function with a single creatinine measurement in kidney transplant patients, mainly due to excessive analytical imprecision. However, our results suggest that capillary blood testing with the StatSensor® can be used for daily trend monitoring of kidney function after renal transplantation.
- Subjects
CREATININE; KIDNEY transplantation; HEPARIN; ENZYMES; TRANSPLANTATION of organs, tissues, etc.
- Publication
Clinical Chemistry & Laboratory Medicine, 2015, Vol 53, Issue 10, p1547
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2014-0932