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- Title
Sensitivity to Interferon-Alpha and Interferon-Stimulated Gene Factor 3 Binding Activity in Human Chronic Myelogenous Leukemia Cell Line KT-1.
- Authors
Yamauchi, Hayato; Sakai, Ikuya; Narumi, Hiroshi; Soga, Shinji; Fujita, Shigeru
- Abstract
The mechanism of responsiveness of chronic myelogenous leukemia (CML) cells to interferon (IFN)-α was examined by using two subclones of CML cell line KT-1 which exhibited significantly different sensitivities to the antiproliferative and apoptosis-inducing effects of IFN-α. IFN-stimulated gene factor 3 (ISGF3) formation by IFN-α was reduced in the IFN-α-resistant subclone compared to the IFN-α-sensitive subclone. We conclude that the level of ISGF3 formation is responsible for the difference in IFN-α responses between these subclones.Copyright © 2000 S. Karger AG, Basel
- Subjects
MYELOID leukemia; NONLYMPHOID leukemia; BONE marrow diseases; INTERFERONS; ANTINEOPLASTIC agents; CELL lines
- Publication
Acta Haematologica, 2000, Vol 104, Issue 1, p1
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000041061