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- Title
Does sleep disturbance affect the amyloid clearance mechanisms in Alzheimer's disease?
- Authors
Yulug, Burak; Hanoglu, Lutfu; Kilic, Ertugrul
- Abstract
Sleep is an important factor that plays a key role in Alzheimer's disease pathogenesis. However, it is still unclear whether poor-quality sleep may overlap with sleep disturbances in the underlying dysfunctional mechanisms of amyloid beta (Aβ) clearance metabolism. Here, we aimed to evaluate the current evidence on the role of sleep deprivation in Aβ clearance metabolism. To that end, we discuss possible mechanisms underlying the bidirectional interaction between the sleep deprivation and Aβ clearance pathways.
- Subjects
ALZHEIMER'S disease; AMYLOID beta-protein; SLEEP deprivation; CEREBROSPINAL fluid; RISK factors of neurodegeneration; DIAGNOSIS
- Publication
Psychiatry & Clinical Neurosciences, 2017, Vol 71, Issue 10, p673
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1111/pcn.12539