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- Title
Increased Shear Rate Resistance and Fastest Kinetics of Erythrocyte Aggregation in Diabetes Measured With Ultrasound.
- Authors
Cloutier, Guy; Zimmer, Audrey; Yu, Francois T. H.; Chiasson, Jean-Louis
- Abstract
OBJECTIVE -- To measure with ultrasound the increased erythrocyte aggregation (EA) kinetics and adhesion energy between erythrocytes in patients with type 2 diabetes and poor metabolic control. RESEARCH DESIGN AND METHODS -- Blood samples were analyzed in a Couette rheometer at 32 MHz following shear rate reductions from 500 s-1 to residual shears of 0 (stasis), 1, 2, 10, 50, 100, and 200 s-1. The increase in EA was determined with the integrated backscatter coefficient as a function of time and shear rate. RESULTS -- The time required to form aggregates was shorter in diabetic patients at shear rates below 200 s-1 (P < 0.01). Erythrocytes formed larger aggregates in diabetic patients than in control subjects (P < 0.05 at 2 to 100 s-1). CONCLUSIONS -- Ultrasound can potentially noninvasively demonstrate, in vivo and in situ, the impact of local abnormal EA on arteriovenous flow disorders in diabetes.
- Subjects
ERYTHROCYTES; TYPE 2 diabetes; DIABETES; METABOLIC regulation; ULTRASONIC imaging
- Publication
Diabetes Care, 2008, Vol 31, Issue 7, p1400
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc07-1802