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- Title
Human papillomavirus vaccine efficacy in the prevention of anogenital warts: systematic review and meta-analysis.
- Authors
Tejada, Romina A.; Vargas, Kris G.; Benites-Zapata, Vicente; Mezones-Holguín, Edward; Bolaños-Díaz, Rafael; Hernández, Adrián V.
- Abstract
Objective. To review evidence on the efficacy of HPV vaccines in the prevention of non-cancer lesions (anogenital warts [AGW], recurrent laryngeal papillomatosis and oral papillomatosis). Materials and methods. We conducted a systematic review of randomized trials. We performed random effect models and effects were reported as relative risks (RR) and their confidence intervals (95%CI) following both intention to treat (ITT) and per protocol (PP) analyses. Results. We included six studies (n=27 078). One study was rated as high risk of bias. One study could not be included in the meta-analysis because it provided combined results. We found that quadrivalent vaccine reduced the risk of AGW by 62% (RR: 0.38, 95%CI:0.32-0.45, I2:0%) in the ITT analysis and by 95% (RR: 0.05, 95%CI:0.01-0.25, I2:66%) in the PP analysis. Subgroup analyses of studies in women or with low-risk of bias provided similar results. Conclusion. HPV quadrivalent vaccine is efficacious in preventing AGW in men and women.
- Subjects
RELATIVE medical risk; HUMAN papillomavirus vaccines; WARTS treatment; META-analysis; QUALITY of life
- Publication
Salud Pública de México, 2017, Vol 59, Issue 1, p84
- ISSN
0036-3634
- Publication type
Article
- DOI
10.21149/7824