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- Title
Serum sodium on admission affects postoperative in-hospital mortality in acute aortic dissection patients.
- Authors
Huang, Pengfei; Wang, Hongyan; Ma, Dong; Zhao, Yongbo; Liu, Xiao; Su, Peng; Zhang, Jinjin; Ma, Shuo; Pan, Zhe; Shi, Juexin; Hou, Fangfang; Zhang, Nana; Zheng, Xiaohui; Liu, Nan; Zhang, Ling
- Abstract
Background: Acute aortic dissection (AAD) is very fatal without surgical treatment. Higher serum sodium can increase in-hospital mortality of many diseases; however, the effect of serum sodium on postoperative in-hospital mortality in AAD patients remains unknown. Methods: We collected a total of 415 AAD patients from January 2015 to December 2019. Patients were classified into four categories (Q1-Q4) according to the admission serum sodium quartile. The cox proportional hazards model evaluated the association between serum sodium and in-hospital mortality. All-cause in-hospital mortality was set as the endpoint. Results: By adjusting many covariates, cox proportional hazards model revealed the in-hospital mortality risk of both Q3 and Q4 groups was 3.086 (1.242–7.671, P = 0.015) and 3.370 (1.384–8.204, P = 0.007) respectively, whereas the risk of Q2 group was not significantly increased. Univariate and multiple Cox analysis revealed that Stanford type A, serum glucose, α-hydroxybutyrate dehydrogenase and serum sodium were risk factors correlated with in-hospital death in AAD patients. Conclusion: The study indicates that the admission serum sodium of AAD patients has a vital impact on postoperative hospital mortality.
- Subjects
HOSPITAL mortality; AORTA; AORTIC dissection; PROPORTIONAL hazards models; SODIUM; MORTALITY
- Publication
PLoS ONE, 2021, Vol 16, Issue 12, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0261168