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- Title
Argon Atmospheric Plasma Treatment Promotes Burn Healing by Stimulating Inflammation and Controlling the Redox State.
- Authors
Souza, Lucas Buzeli de; Silva, Jennyffer Ione de Souza; Bagne, Leonardo; Pereira, Amanda Tavares; Oliveira, Maraiara Aparecida de; Lopes, Bruno Bellotti; Amaral, Maria Esméria Corezola do; de Aro, Andrea Aparecida; Esquisatto, Marcelo Augusto Marretto; Santos, Gláucia Maria Tech dos; Andrade, Thiago Antônio Moretti de
- Abstract
Burns are a public health problem, with second-degree burns as one of the most common types. Although intense inflammation worsens burn healing, effective therapies are scarce. Thus, infections and hypertrophic scars may occur, which compromise patient quality of life and may delay healing. Argon atmospheric plasma (AP) has been shown to positively influence wound healing. In the context of identifying effective and alternative therapies for the treatment of second-degree burns, the present study evaluated AP in the treatment of second-degree burns in rats compared to that for sham treatment on the 2nd, 7th, 14th, and 21st days post-injury. Our results revealed proinflammatory effect for AP by recruiting predominantly neutrophils on the 7th day and macrophages on the 21st day compared to sham treatment, allowing a greater production of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-17, and also controlled the inflammation by IL-10 and transforming growth factor (TGF)-β1. AP also showed antioxidant activity important for controlling oxidative damage on the 2nd day. This favored the induction of angiogenesis from the 2nd day and induction fibroplasia and fibrillogenesis after the 14th day, which enhanced burn healing with the formation of a thinner burn eschar before the 21st day post-burn. Thus, AP effectively modulated the inflammatory phase of second-degree burn healing through the control of oxidative damage that favored the following phases. Therefore, AP is a relevant alternative in the treatment of second-degree burns.
- Subjects
ARGON plasmas; TRANSFORMING growth factors; TUMOR necrosis factors; OXIDATION-reduction reaction; INFLAMMATION; HYPERTROPHIC scars
- Publication
Inflammation, 2020, Vol 43, Issue 6, p2357
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-020-01305-x